We recently have just received results from a research task that has been in the works for around two years.
The results are back and cannot be denied. DNA testing has revealed the existence of Neonatal Hypothyroidism (more accurately known as Congenital Hypothyroidism with Goiter, or CHG) in Tenterfield Terriers. The breeders that showed the interest and sought answers to the unusual development of some puppies should be congratulated. It is now up to us all to ensure this does not continue to be hidden.
I understand that initial reaction to this diagnosis will be denial, however, we can only deny this inheritable disease for so long. History has proven that denial of inheritable disease in various breeds has led to many breeds now undergoing high levels of regulation by the ANKC and litter registration restrictions. We do not want to see this happen within the Tenterfield Terrier breed and this is why we are choosing to provide this information to our members.
What is it?
Neonatal Hypothyroidism is a disease affecting only young puppies and it is fatal. For many years now we believe that incidence of Neonatal Hypothyroidism has been misdiagnosed by breeders and vets alike as ‘fading puppy syndrome’.
Basically pups appear completely normal and progress as normal up until 2 weeks of age. They, then start deteriorating, develop feeding difficulties, loose co-ordination, loose the ability to regulate their own body and temperatures, their eyes and ears fail to open, develop a fluffy coat and growth is very stunted. Affected pups do not survive long enough to make it to their 6 week vaccination either by demise or euthanasia.
Are their any risks of selling an affected pup?
Absolutely not. Pups affected by this disease do not survive long enough to make it to 8 weeks of age.
Can a carrier ever be affected by this?
No - The information we have to hand is that at no time will a carrier ever develop any conditions directly related to this defective gene.
What does this mean for our breeding programs?
We need to educate ourselves about this disease and make breeding choices that will assist in the control and possible elimination of this disease in Tenterfield Terriers.
Research has shown that this disease is an autosomal recessive gene. What this means is, to end up with an affected pup you need to obtain a double up of the defective gene. That is, both parents must be carriers. Consequently, if only one of a breeding pair is a carrier, they will never produce an affected pup, but will produce puppies that may be carriers.
To further explain this, a mating of carrier to clear will result in approximately 50/50 ratio of carrier & clear puppies.
I should also highlight that a clear to clear mating will never result a carrier pup, let alone an affected pup.
What do we do now?
First off is to arm yourself with all available information. There is absolutely no need to panic or eliminate any or all carriers from your breeding programs. The exclusion of carriers from our already small breeding pool with only do our breed harm by concentrating undesirable characteristics and essentially taking our development back many, many, years. Testing is the way of the future!
By testing, you arm yourself with the knowledge to make informed breeding choices and at this early stage it gives us room to move forward over the coming years, to work towards the reduction and eventual elimination of this disease within our breed. However, the total elimination of this disease will likely take decades to happen. But it will only happen once all Tenterfield Terrier breeders take responsibility.
Why should we test?
We are all obligated by the ANKC Code of Practice to do all that we can to identify and eliminate inheritable diseases by making informed breeding choices.
Where do I get more information?
Dr Day has very kindly offered to answer any queries our members may have in regards to this and she can co-ordinate any testing that you would like to organize. Dr Day’s contact details are as follows:
Dr Rebekah Day, BVSc, Cert (AQIS), Cert (IVAS)
Alpine Animal Doctors
7047 Great Alpine Rd,
Porepunkah, Vic 3740
Ph: 613 5756 2444
Fax: 613 5756 2044
Please remember though that Dr Day owns and operates a very busy veterinary practice, so please be patient when waiting for a response.
We will also continue to provide further information as it becomes available. Our sincere thanks go to Dr Rebekah Day. Dr Rebekah Day has been instrumental in identifying this previously undiagnosed congenital issue and organising the research and testing for this disease. If it wasn’t for her proactive attitude (something that is often lacking these days), we would still be in the dark. Just to update you all on the latest information to hand regarding testing for this disease we hope to be able to offer you a Bucal (cheek) Swab test in the very near future. This has been held up due to insufficient funding. Thank you to all members who donated money towards this research.